ULK3orunc-51-likekinase3isamemberoftheserine/threoninekinasefamilythatisinvolvedintheSHHsignalingpathwayasapositiveregulatorofGLIproteins(1).ULK3enhancesendogenousandover-expressedGLItranscriptionalactivityinculturedcellsandaltersitssubcellularlocalization.Fur
Thermore,ULK3phosphorylatesGLIproteinsinvitro.ULK3iswidelyexpressedanditsexpressionishigherinanumberoftissueswhereSHHsignalingisknowntobeactive,againsuggestingthatULK3isinvolvedintheSHHpathwayasapositiveregulatorofGLIproteins.