Bpsbioscience/NSD2 (catalytic domain), GST-tag/51026/50 µg,BPS Bioscience,,BPS Bioscience,bpsbioscience,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Bpsbioscience/NSD2 (catalytic domain), GST-tag/51026/50 µg

产品编号：51026

市场价：¥9000.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$450.00

品牌： BPS Bioscience

公司：BPS Bioscience Inc.

公司分类：

商品介绍

Species: Human

Host Species: E. coli

MW: 62 kDa

Genbank #: NM_133330

Tag(s): N-terminal GST-tag

a.a: 941–1240

Background:

NSD2 is a histone methyltransferase that preferentially methylates Lys27 of histone H3. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Mutations in the gene for NSD2 are linked to Wolf-Hirschhorn syndrome (WHS), a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4, and is also associated with chromosomal translocations in multiple myelomas.

Description:

Human NSD2, also known as RE-IIBP, MMSET, and WHSC1 (GenBank Accession No. NM_133330), a.a. 941-1240 (catalytic domain) with N-terminal GST-tag, MW = 62 kDa, expressed in E. coli.

UniProt

O96028

Synonym(s):

WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET Domain-Containing Protein 2, REIIBP, WHS, TRX5

Specific Activity:

0.036 pmol/min/µg

Assay Conditions:

Assay was performed using the BPS NSD2 Chemiluminescent Assay Kit (Cat. #53009) according to recommended protocol, with 5 µM S-adenosylmethionine on biotinylated H3 peptide-coated plates. Enzyme reaction was performed for 2 hours at room temperature.

Formulation:

50 mM Tris-HCl, pH 8.5, 300 mM NaCl, 5 mM DTT, 10 mM glutathione, and 10% glycerol.

Format:

Aqueous buffer solution

Storage / Stability:

>6 months at -80°C.

Application(s):

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Reference(s):

1. Kassambara A. et al., Biochem. Biophys. Res. Commun. 379 (4), 840-845 (2009).
2. Brito J.L. et al., Haematologica 94 (1), 78-86 (2009).

Warning(s):

Avoid freeze/thaw cycles

Scientific Category:

Methyltransferase

Product Type:

Recombinant Protein

Data shown is lot-specific. Contact us for specific information on other lots.

品牌介绍

BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系

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