主营：激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
℡ 4000-520-616
℡ 4000-520-616
商品介绍
Species: Human
Host Species: E. coli
MW: 21 kDa
Genbank #: NM_007019
Tag(s): N-Terminal His-Tag
Background:
UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C.
Description:
Recombinant full-length Human UBE2C, also known as dJ447F3.2, and UBCH10. Genbank Accession No. NM_007019, with an N-terminal His-tag, expressed in E. Coli cells via a baculovirus expression system. MW=21 kDa.
Synonym(s):
dJ447F3.2, UBCH10
Formulation:
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol.
Storage / Stability:
At least 6 months at –70°C. Avoid freeze/thaw cycles.
Application(s):
Useful for the study of ubiquitin enzyme kinetics, and as a positive control for Western blot studies.
Reference(s):
1. Mondal, S., et al., Anal. Biochem. 2016; 510: 41-51.
2. Rape, M., et al., Nature. 2004; 432: 588-595.
Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Ubiquitination
Product Type:
Activating Enzyme
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型 重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系
公司介绍
产品分类
Protease(s)
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Methyl-lysine Reader(s)
Deacetylase(s)
Acetyltransferase(s)
Metabolic Enzymes
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Other Proteins
Immunotherapy
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Phospholipase(s)
Ubiquitination
Bromodomain(s)
Biotinylation
Molecular Biology Tools
Inhibitors / Activators
Methyltransferase(s)
Heat Shock Protein
PARP(s)
Cell Based Assay Kits
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Demethylase(s)
Protein Arginine Deiminase(s)
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