Bpsbioscience/MuRF3, SUMO-His-tags/81054/25 µg,BPS Bioscience,,BPS Bioscience,bpsbioscience,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Bpsbioscience/MuRF3, SUMO-His-tags/81054/25 µg

产品编号：81054

市场价：¥7100.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$355.00

品牌： BPS Bioscience

公司：BPS Bioscience Inc.

公司分类：

商品介绍

Species: Human

Host Species: E. coli

MW: 40.3 kDa (without SUMO tag)

Genbank #: Q9BYV2

Tag(s): N-terminal SUMO-His-tags

a.a: full length

Background:

MuRF3 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. MuRF3 has been demonstrated to function with the E2 enzyme UBE2D3 (UbcH5c) in vitro. MuRF3 is also known as TRIM54 (tripartite motif containing 54) containing a RING-finger/B-box/coiled-coil tripartite fold. MuRF3 has been implicated along with MuRF1 as regulators of protein degradation in striated muscle. MuRF3 also plays important roles in maintaining cardiac function after myocardial infarction.

Description:

Human MuRF3 recombinant protein (Genbank Accession No. Q9BYV2), full length with N-terminal SUMO- and His-tags, expressed in E. coli.

UniProt

Q9BYV2

Synonym(s):

E3 ubiquitin-protein ligase TRIM54, MURF3, MuRF-3, MURF-3, Muscle-specific RING finger protein 3, RING finger protein 30, RNF30, Tripartite motif-containing protein 54

Purity:

≥90% by SDS-PAGE

Biological Activity:

Typical enzyme concentration of 20-1000 nM is used for in vitro conjugation depending on assay conditions.

Formulation:

50 mM Tris Buffer, pH 7.6, 150 mM NaCl, 10% glycerol

Format:

Aqueous buffer solution

Storage / Stability:

Stable for ≥1 year at –80°C.

Application(s):

Useful as an E3 ligase in ubiquitin-conjugating reactions and to analyze upregulation/downregulation of E3 enzymes.

Reference(s):

1. Balasubramanian, S., et al. Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. J. Mol. Cell Cardiol., 2006. 41(4): p. 669-79.
2. Fielitz, J., et al. Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. J. Clin. Invest., 2007. 117(9): p. 2486-95.
3. Fielitz, J., et al. Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Proc. Natl. Acad. Sci. USA, 2007. 104(11): p. 4377-82.

Warning(s):

Avoid freeze/thaw cycles.

Scientific Category:

Ubiquitination (Ubiquitin Ligase (E3))

Product Type:

Recombinant Protein

Data shown is lot-specific. Contact us for specific information on other lots.

品牌介绍

BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系

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