主营：激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
℡ 4000-520-616
℡ 4000-520-616
商品介绍
Species: Human
Host Species: FreeStyle 293-F cells
MW: 53 kDa
Genbank #: NM_005040
Tag(s): C-terminal His-tag
a.a: 31–496
Background:
PrCP is a lysosomal prolylcarboxypeptidase that cleaves C-terminal amino acids linked to proline. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. PrCPs role in angiotension II cleavage, which regulates blood pressure and electrolyte balance, suggests that PrCP may be involved in hypertension.
Description:
Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession #NM_005040), a.a. 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.
UniProt
P42785
Synonym(s):
Proline Carboxypeptidase, Angiotensinase C, PCP, Lysosomal Pro-X carboxypeptidase
Formulation:
40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, 200 mM imidazole
Format:
Aqueous buffer solution
Storage / Stability:
Stable at least 6 months from date of receipt, when stored as directed
Application(s):
Useful for the cleavage of C-terminal amino acids linked to proline in peptides, for example, angiotension II, III and des-Arg9-bradykinin.
Reference(s):
1. Tan, F., et al. 1993. J Biol Chem 268 (22): 16631–8.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Protease
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型 重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系
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