Rucaparib,alsonamedasAG-014699orPF-01367338,isapoly(ADPribose)polymerase(PARP)inhibitor.PARPisaDNAdamage-activatednuclearenzymethathasakeysignalingroleinthebaseexcisionrepairpathway.So,rucaparibhasbeenalsofoundtobemosteffectiveincellsdeficientinDNArepair,wherethecellsdeficientarecausedbyexposuretogenotoxicagents,suchasirr
ADIationproducesDNAdamageanditstoxicityisaugmentedwhentheDNArepairisimpaired.IncreasedradiosensitivityinpresenceofrucaparibwasassociatedwithpersistentDNAbreaksasdeterminedbygamma-H2AXandp53BP1foci.Rucaparibradiosensitizesprostatecancercells,mosteffectivelythosethatarePTEN-deficientandareexpressingETSgenefusionproteins,whichinhibitsNHEJDNArepair.