主营：激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
℡ 4000-520-616
℡ 4000-520-616
商品介绍
MW: 315.8 Da
CAS Registry #: 175178-82-2
Formula: C16H14ClN3O2
Description:
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Much weaker inhibitor of PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner.
Synonym(s):
AG 1478
Purity:
≥99%
Solubility:
Soluble in DMSO at 50 mg/ml; soluble in ethanol at 25 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Format:
A white solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Osherov, N. and Levitzki, A. Eur. J. Biochem. 225: 1047-1053 (1994).
2. Levitzki, A. and Gazit, A. Science 267: 1782-1788 (1995).
3. Choi, B.H., et al. Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
2. Levitzki, A. and Gazit, A. Science 267: 1782-1788 (1995).
3. Choi, B.H., et al. Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
Scientific Category:
Kinase
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型 重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系
公司介绍
产品分类
Protease(s)
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