主营：激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶
℡ 4000-520-616
℡ 4000-520-616
商品介绍
MW: 556.4 Da
CAS Registry #: 1134156-31-2
Formula: C25H23Cl2N7O4
Target: HSP70
Background:
VER 155008 is a potent inhibitor of heat shock protein 70 (Hsp70) family of chaperones, which have been shown to contribute to cancer cell survival via anti-apoptotic functions, that inhibits Hsp70 (IC50 = 0.5 µM) as well as heat shock cognate 71 kDa protein (Hsc70) and 78 kDa glucose-regulated protein (Grp78) to a lesser extent. X-ray crystallography analysis reveals that VER 155008 binds to the ATPase pocket of Hsp70 leading to the inhibition of the intrinsic ATPase activity of Hsp70. Study results also have demonstrated that VER 155008 induces cell proliferation and apoptosis in human cancer cell lines.
Description:
VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.
Synonym(s):
adenosine-derived inhibitor; VER155008; VER-155008; me 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile
Solubility:
Soluble in DMSO
Format:
white to light brown powder
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Massey AJ, et al. Cancer Chemother Pharmacol. 2010; 66(3): 535-545
Warning(s):
Protect from moisture.
Scientific Category:
HSP Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型 重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系
公司介绍
产品分类
Protease(s)
Antibodies
Methyl-lysine Reader(s)
Deacetylase(s)
Acetyltransferase(s)
Metabolic Enzymes
Kinase(s)
Phosphodiesterase(s)
Other Proteins
Immunotherapy
Apoptosis
Cell Surface Receptor(s)
Phospholipase(s)
Ubiquitination
Bromodomain(s)
Biotinylation
Molecular Biology Tools
Inhibitors / Activators
Methyltransferase(s)
Heat Shock Protein
PARP(s)
Cell Based Assay Kits
Cytokine(s)
Products
New Products
Caspase-3
Demethylase(s)
Protein Arginine Deiminase(s)
Neuroscience
销售排行
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限时必达 不达必赔
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