DAPK3orDeath-associatedproteinkinase3(alsoknownasZIP)playsaroleinapoptosis(1).DAPK3isanuclearserine/threonine-specifickinasethatphosphorylatescorehistonesH3andH4,andmyosinelightchaininvitro.DAPK3interactswithtranscriptionandsplicingfactorsaswellaswithpro-apoptoticproteinPar-4suggestingthatitparticipatesinmultiplecellularprocesses.DAPK3containsaleucinezipperstructureatitsCterminusandthisregionisrespons
IBLeforbindingtoATF4.TheleucinezipperdomainisnecessaryforthehomodimerizationofDAPK3aswellasfortheactivationofthekinase(2).