Bpsbioscience/Human Interleukin-21/90186-A/2 µg,BPS Bioscience,,BPS Bioscience,bpsbioscience,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Bpsbioscience/Human Interleukin-21/90186-A/2 µg

产品编号：90186-A

市场价：¥2600.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$130.00

品牌： BPS Bioscience

公司：BPS Bioscience Inc.

公司分类：

商品介绍

Species: Human

Host Species: E. coli

MW: 15 kDa

Genbank #: Q9HBE4

a.a: 25–155

Background:

IL-21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T-cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on NK-cells, T- cells, and B-cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3.

Description:

Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.

UniProt

Q9HBE4

Synonym(s):

Interleukin 21, IL-21, Za11

Purity:

≥97% by SDS-PAGE and HPLC

Endotoxin Level:

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Biological Activity:

The ED₅₀ was determined by the dose-dependent proliferation of activated B-cells.

Formulation:

Lyophilized from 0.2 µm filtered PBS, pH 7.5.

Format:

lyophilized protein

Reconstitution:

Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.

Storage / Stability:

The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.

Reference(s):

1. Pallikkuth, S., et al. Crit Rev Immunol. 2012,32(2):173-95.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70.
3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6.

Warning(s):

Avoid freeze/thaw cycles

Amino Acid Sequence:

QDRHMI RMRQLIDIVD QLKNYVNDLV PEFLPAPEDV ETNCEWSAFS CFQKAQLKSA NTGNNERIIN VSIKKLKRKP PSTNAGRRQK HRLTCPSCDS YEKKPPKEFL ERFKSLLQKM IHQHLSSRTH GSEDS

Scientific Category:

Cytokine/Growth Factors

Product Type:

Recombinant Protein

Data shown is lot-specific. Contact us for specific information on other lots.

品牌介绍

BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系

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