CARP2(caspase8/10associatedRINGprotein2)isaRING-domainE3(ubiquitinproteinligase)thatisinvolvedintheconjugationofubiquitintotargetsubstrates,alongwithE1andE2enzymes.CARPs(CARP1andCARP2,77%identity)alsobelongtotheIAPfamily(inhibitorsofapoptosisproteins)inhibitingactivationofDED(deatheffectordomain)containingcaspaseproteins(8and10).Inadditiontotargetingcaspases8and10,CARPshavebeenshowntotargetphosphorylatedp53fordegradationinanHdm2independentmanner.Fur
Thermore,CARP2hasbeenshowntobeanegativeregulatorofTNFinducedNF-kappaBactivationbytargetingRIPfordegradation.