Polycombgroup(PcG)proteinthatspecificallyrecognizesandbindsmono-anddimethyl-lysineresiduesontargetproteins,thereyactingasareaderofanetworkofpost-translationalmodifications.PcGproteinsmaintainthetranscriptionallyrepressivestateofgenes:actsasachromatincompactionfactorbyrecognizingandbindingmono-anddimethylatedhistoneH1b/HIST1H1EatLys26(H1bK26me1andH1bK26me2)andhistoneH4atLys-20(H4K20me1andH4K20me2),le
ADIngtocondensechromatinandrepresstranscription.Recognizesandbindsp53/TP53monomethylatedatLys-382,leadingtorepressp53/TP53-targetgenes.AlsorecognizesandbindsRB1/RBmonomethylatedatLys-860.ParticipatesintheETV6-mediatedrepression.Probablyplaysaroleincellproliferation.Overexpressioninducesmultinucleatedcells,suggestingthatitisrequiredtoaccomplishnormalmitosis.