Bpsbioscience/Alvespimycin HCl (17-DMAG)/27730-2/100 mg,BPS Bioscience,,BPS Bioscience,bpsbioscience,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Bpsbioscience/Alvespimycin HCl (17-DMAG)/27730-2/100 mg

产品编号：27730-2

市场价：¥6600.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>细胞因子>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$330.00

品牌： BPS Bioscience

公司：BPS Bioscience Inc.

公司分类：

商品介绍

MW: 653.2 Da

CAS Registry #: 467214-21-7

Formula: C₃₂H₄₈N₄O₈ • HCl

Target: HSP90

Background:

Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

Description:

Alvespimycin HCl, also known as 17-DMAG, is a potent, water-soluble HSP90 inhibitor. Alvespimycin has diverse anti-tumor actions and has potential in treating a number of different types of cancers, including ovarian, prostate, melatnoma, non-small-cell lung cancer, and several leukemias (chronic lymphocytic, acute myeloid). This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.

Synonym(s):

17-DMAG; KOS-1022; NSC707545; 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin

Purity:

≥95% by HPLC

Biological Activity:

Alvespimycin (also known as 17-DMAG) displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM.

Solubility:

Soluble in DMSO (100 mM). Solubility in water is less than 1 mg/ml (1 mM).

Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):

1. Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126.
2. Lancet JE, et al. 2010 Apr;24(4):699-705.

Scientific Category:

HSP Inhibitor

Product Type:

Inhibitor

Data shown is lot-specific. Contact us for specific information on other lots.

品牌介绍

BPS bioscience总部坐落于世界最大之一的美国圣地亚哥生命科学研究机构和公司集中地的中心。公司主要提供激酶、磷酸二酯酶、磷酸酶、组蛋白去甲基化酶、组蛋白甲基化转移酶、HDACs、聚ADP核糖聚合酶。BPS公司为药物研发用重组酶类的提供了最大选择之一。产品类型重组酶类；分子细胞生物学；重组蛋白；分析试剂盒；底物；重组细胞系

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