(S)-MG132,alsoknownasZ-Leu-Leu-Leu-CHO,isapotent,reversIBLeandcell-permeableinhibitorofproteasomesthatinhibitscellgrowthinB16andIPC227Fcells.ItalsoinhibitsNF-κBactivation,sensitizingavarietyofcarcinomacelllinestoapoptosis.
≥98%byHPLC
(S)-MG132inhibitscellgrowthinB16andIPC227FcellswithIC50valuesof42nMand77nM,respectively.
Solubleinethanol,DMSOandDMF,purgedwithaninertgas.Solubilityinthesesolventsisapproximately25mg/ml.
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
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