EZH2isthecatalyticsubunitofthePRC2/EED-EZH2complex,whichmethylatesLys9(H3K9me)andLys27(H3K27me)ofhistoneH3,le
ADIngtotranscriptionalrepressionoftheaffectedtargetgene.Abletomono-,di-andtrimethylateLys27ofhistoneH3toformH3K27me1,H3K27me2andH3K27me3,respectively.ComparedtoEZH2-containingcomplexes,itismoreabundantinembryonicstemcellsandplaysamajorroleinformingH3K27me3,whichisrequiredforembryonicstemcellidentityandproperdifferentiation.ThePRC2/EED-EZH2complexmayalsoserveasarecruitingplatformforDNAmethyltransferases,therebylinkingtwoepigeneticrepressionsystems.GenesrepressedbythePRC2/EED-EZH2complexincludeHOXC8,HOXA9,MYT1,CDKN2Aandretinoicacidtargetgenes.EZH2canalsomethylatenon-histoneproteinssuchasthetranscriptionfactorGATA4.